MolNFT v1 · #187327 · protein
Cryogenic human HSP90A-ntd bound to BIIB021
7S9F · Heat shock protein HSP 90-alpha: “Cryogenic human HSP90A-ntd bound to BIIB021”. X-ray diffraction, 2 ligands (94M, MG), 1 pocket (best druggability 0.70). MolNFT v1 #187327 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7S9F
- Type
- protein
- Length
- 214 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heat shock protein HSP 90-alpha
- EC
- 3.6.4.10
- UniProt
- P07900
- Ligands
- 94M, MG
- Pockets
- 1 · best druggability 0.70
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Heat shock protein HSP 90-alpha (EC 3.6.4.10) | protein | 214 | 42% helix, 23% strand | P07900 |
Ligands and binding sites
- 94M · 6-chloro-9-[(4-methoxy-3,5-dimethylpyridin-2-yl) methyl]-9H-purin-2-amine · ligand · chains A
- MG · Magnesium ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 350 | 0.70 | 0.82 | 36 | 94M |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07900
- Elsewhere: RCSB PDB 7S9F · PDBe 7S9F · UniProt P07900
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.