MolNFT v1 · #187326 · protein
Cryo-EM structure of dolphin prestin: inhibited II (sulfate +salicylate) state
7S9E: “Cryo-EM structure of dolphin prestin: inhibited II (sulfate +salicylate) state”. Electron microscopy, 1 ligand (SAL), 20 pockets (best druggability 0.84). MolNFT v1 #187326 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7S9E
- Type
- protein
- Length
- 1,354 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Prestin
- UniProt
- D7PC76
- Ligands
- SAL
- Pockets
- 20 · best druggability 0.84
Structure
electron microscopy · 1 distinct chain · 58% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Prestin | protein | 677 | 58% helix, 5% strand | D7PC76 |
Ligands and binding sites
- SAL · 2-hydroxybenzoic acid · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 801 | 0.84 | 0.87 | 77 | empty |
| 2 | 929 | 0.75 | 0.78 | 88 | empty |
| 3 | 891 | 0.75 | 0.78 | 80 | empty |
| 4 | 66 | 0.73 | 0.97 | 20 | SAL |
| 5 | 68 | 0.73 | 0.97 | 20 | SAL |
Interfaces
1 interface between chains.
- A–B · 3957 Ų buried · 47 hydrogen bonds · protein-protein
Compared structures
- 7S9E · Cryo-EM Structure of dolphin Prestin: Inhibited II (Sulfate +Salicylate) state · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt D7PC76
- Elsewhere: RCSB PDB 7S9E · PDBe 7S9E · UniProt D7PC76
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