MolNFT v1 · #187325 · protein
Cryo-EM structure of dolphin prestin: intermediate state
7S9D: “Cryo-EM structure of dolphin prestin: intermediate state”. Electron microscopy, 20 pockets (best druggability 0.84). MolNFT v1 #187325 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7S9D
- Type
- protein
- Length
- 1,354 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Prestin
- UniProt
- D7PC76
- Pockets
- 20 · best druggability 0.84
Structure
electron microscopy · 1 distinct chain · 55% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Prestin | protein | 677 | 55% helix, 4% strand | D7PC76 |
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 597 | 0.84 | 0.89 | 61 | empty |
| 2 | 1062 | 0.77 | 0.79 | 105 | empty |
| 3 | 818 | 0.74 | 0.79 | 78 | empty |
| 4 | 596 | 0.73 | 0.80 | 79 | empty |
| 5 | 471 | 0.72 | 0.82 | 64 | empty |
Interfaces
1 interface between chains.
- A–B · 3492 Ų buried · 52 hydrogen bonds · protein-protein
Compared structures
- 7S9D · Cryo-EM Structure of dolphin Prestin: Intermediate state · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt D7PC76
- Elsewhere: RCSB PDB 7S9D · PDBe 7S9D · UniProt D7PC76
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