MolNFT v1 · #187311 · protein
Cryo-EM structure of dolphin prestin: sensor up (compact) state
7S8X: “Cryo-EM structure of dolphin prestin: sensor up (compact) state”. Electron microscopy, 20 pockets (best druggability 0.85). MolNFT v1 #187311 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7S8X
- Type
- protein
- Length
- 1,350 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Prestin
- UniProt
- D7PC76
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 1 distinct chain · 60% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Prestin | protein | 675 | 60% helix, 5% strand | D7PC76 |
Pockets
20 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 837 | 0.85 | 0.87 | 77 | empty |
| 2 | 834 | 0.73 | 0.78 | 94 | empty |
| 3 | 191 | 0.67 | 0.86 | 35 | empty |
| 4 | 465 | 0.66 | 0.78 | 50 | empty |
| 5 | 305 | 0.61 | 0.79 | 34 | empty |
Interfaces
1 interface between chains.
- A–B · 3882 Ų buried · 50 hydrogen bonds · protein-protein
Compared structures
- 7S8X · Cryo-EM Structure of dolphin Prestin: Sensor Up (compact) state · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt D7PC76
- Elsewhere: RCSB PDB 7S8X · PDBe 7S8X · UniProt D7PC76
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