MolNFT v1 · #18727 · protein
BETA2 microglobulin mutant H31Y displays hints for amyloid formations
1PY4 · Beta-2-microglobulin precursor: “BETA2 microglobulin mutant H31Y displays hints for amyloid formations”. X-ray diffraction, 4 pockets (best druggability 0.64). MolNFT v1 #18727 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 1PY4
- Type
- protein
- Length
- 388 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Beta-2-microglobulin precursor
- UniProt
- P61769
- Pockets
- 4 · best druggability 0.64
Structure
x-ray diffraction · 3 distinct chains · 0% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Beta-2-microglobulin precursor | protein | 98 | 0% helix, 52% strand | P61769 |
| B, D | Beta-2-microglobulin precursor | protein | 97 | 0% helix, 53% strand | P61769 |
| C | Beta-2-microglobulin precursor | protein | 96 | 0% helix, 49% strand | P61769 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 403 | 0.64 | 0.78 | 35 | empty |
| 2 | 90 | 0.56 | 0.86 | 15 | empty |
| 3 | 256 | 0.47 | 0.72 | 29 | empty |
| 4 | 59 | 0.31 | 0.76 | 14 | empty |
Interfaces
4 interfaces between chains.
- A–C · 492 Ų buried · 5 hydrogen bonds · protein-protein
- B–D · 421 Ų buried · 6 hydrogen bonds · protein-protein
- A–D · 268 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 189 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 1PY4 · Beta2 microglobulin mutant H31Y displays hints for amyloid formations · the same entry in another collection · chain D against D, TM-score 1.00
- P61769 · AlphaFold monomer V2.0 prediction for beta-2-microglobulin (P61769) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P61769
- Elsewhere: RCSB PDB 1PY4 · PDBe 1PY4 · UniProt P61769
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.