MolNFT v1 · #187224 · protein
Human katp channel in open conformation, focused on kir (C166S G334D double mutant) and sur TMD0
7S5T · ATP-sensitive inward rectifier potassium channel 11: “Human katp channel in open conformation, focused on kir (C166S G334D double mutant) and sur TMD0”. Electron microscopy, 1 ligand (K), 16 pockets (best druggability 0.87). MolNFT…
- PDB
- 7S5T
- Type
- protein
- Length
- 1,284 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP-sensitive inward rectifier potassium channel 11
- UniProt
- B2RC52
- Ligands
- K
- Pockets
- 16 · best druggability 0.87
Structure
electron microscopy · 1 distinct chain · 31% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | ATP-sensitive inward rectifier potassium channel 11 | protein | 321 | 31% helix, 29% strand | B2RC52 |
Ligands and binding sites
- K · Potassium ion · metal · 2 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
16 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 662 | 0.87 | 0.92 | 81 | empty |
| 2 | 231 | 0.66 | 0.84 | 42 | empty |
| 3 | 240 | 0.64 | 0.82 | 42 | empty |
| 4 | 237 | 0.63 | 0.82 | 44 | empty |
| 5 | 379 | 0.63 | 0.78 | 50 | empty |
Interfaces
6 interfaces between chains.
- B–C · 3424 Ų buried · 32 hydrogen bonds · protein-protein
- C–D · 3423 Ų buried · 33 hydrogen bonds · protein-protein
- A–D · 3421 Ų buried · 32 hydrogen bonds · protein-protein
- A–B · 3401 Ų buried · 31 hydrogen bonds · protein-protein
- A–C · 43 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 7S5T · Human KATP channel in open conformation, focused on Kir (C166S G334D double mutant) and… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B2RC52
- Elsewhere: RCSB PDB 7S5T · PDBe 7S5T · UniProt B2RC52
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