MolNFT v1 · #18721 · protein

Crystal structure of the actin-crosslinking core of arabidopsis fimbrin

1PXY · Fimbrin-like protein: “Crystal structure of the actin-crosslinking core of arabidopsis fimbrin”. X-ray diffraction, 18 pockets (best druggability 0.64). MolNFT v1 #18721 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1PXY
Type: protein
Length: 942 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fimbrin-like protein
UniProt: Q7G188
Pockets: 18 · best druggability 0.64

Structure

x-ray diffraction · 2 distinct chains · 60% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fimbrin-like protein	protein	465	60% helix, 0% strand	Q7G188
B	Fimbrin-like protein	protein	477	60% helix, 0% strand	Q7G188

Pockets

18 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	115	0.64	0.88	20	empty
2	417	0.62	0.77	48	empty
3	302	0.62	0.79	45	empty
4	318	0.62	0.78	43	empty
5	491	0.61	0.75	43	empty

Interfaces

1 interface between chains.

A–B · 647 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

1PXY · Crystal structure of the actin-crosslinking core of Arabidopsis fimbrin · the same entry in another collection · chain A against A, TM-score 1.00
Q7G188 · AlphaFold monomer V2.0 prediction for fimbrin-1 (Q7G188) · a predicted model of the same protein · chain B against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q7G188
Elsewhere: RCSB PDB 1PXY · PDBe 1PXY · UniProt Q7G188

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