MolNFT v1 · #187206 · protein

Crystal structure of the tick evasin eva-P974 complexed to a chimera made of human chemokines CCL7 and CCL8

7S59 · Evasin P974: “Crystal structure of the tick evasin eva-P974 complexed to a chimera made of human chemokines CCL7 and CCL8”. X-ray diffraction, 1 ligand (SO4), 2 pockets (best druggability 0.47). MolNFT v1 #187206 on GenesisL1: 3D…

PDB: 7S59
Type: protein
Length: 306 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Evasin P974; Chimera protein of C-C motif chemokine 7 and C-C motif chemokine 8,C-C motif…
UniProt: A0A023FDY8, P80075, P80098
Ligands: SO4
Pockets: 2 · best druggability 0.47

Structure

x-ray diffraction · 4 distinct chains · 13% helix, 39% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
1	Evasin P974	protein	83	7% helix, 49% strand	A0A023FDY8
3	Evasin P974	protein	84	7% helix, 50% strand	A0A023FDY8
4	Chimera protein of C-C motif chemokine 7 and C-C motif chemokine 8,C-C motif chemokine 7	protein	71	24% helix, 25% strand	P80075, P80098
2	Chimera protein of C-C motif chemokine 7 and C-C motif chemokine 8,C-C motif chemokine 7	protein	68	18% helix, 28% strand	P80075, P80098

Ligands and binding sites

SO4 · Sulfate ion · ion · 2 copies · chains 1, 4

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	129	0.47	0.78	22	empty
2	75	0.32	0.74	15	empty

Interfaces

4 interfaces between chains.

1–2 · 1060 Å² buried · 11 hydrogen bonds · protein-protein
3–4 · 970 Å² buried · 9 hydrogen bonds · protein-protein
1–4 · 379 Å² buried · 6 hydrogen bonds · protein-protein
3–2 · 112 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 12 disulfide (disulfide).

Compared structures

7S59 · Crystal structure of the tick evasin EVA-P974 complexed to a chimera made of human… · the same entry in another collection · chain 2 against 2, TM-score 1.00
P80098 · AlphaFold monomer V2.0 prediction for C-C motif chemokine 7 (P80098) · a predicted model of the same protein · chain 4 against A, TM-score 0.87
P80075 · AlphaFold monomer V2.0 prediction for C-C motif chemokine 8 (P80075) · a predicted model of the same protein · chain 4 against A, TM-score 0.86

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A023FDY8
Every structure of UniProt P80075
Every structure of UniProt P80098
Elsewhere: RCSB PDB 7S59 · PDBe 7S59 · UniProt A0A023FDY8 · UniProt P80075 · UniProt P80098

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.