MolNFT v1 · #187122 · protein

Crystal structure of the NA+/H+ antiporter nhaa at pH 6.5

7S24 · NA(+)/H(+) antiporter nhaa: “Crystal structure of the NA+/H+ antiporter nhaa at pH 6.5”. X-ray diffraction, 7 pockets (best druggability 0.65). MolNFT v1 #187122 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7S24
Type: protein
Length: 375 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: NA(+)/H(+) antiporter nhaa
UniProt: Q53YW7
Pockets: 7 · best druggability 0.65

Structure

x-ray diffraction · 1 distinct chain · 75% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	NA(+)/H(+) antiporter nhaa	protein	375	75% helix, 2% strand	Q53YW7

Ligands and binding sites

OLC · (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate · additive · 2 copies · chains A
1PE · Pentaethylene glycol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	172	0.65	0.85	23	empty
2	136	0.53	0.81	22	empty
3	94	0.41	0.78	20	empty
4	81	0.41	0.78	14	empty
5	115	0.40	0.74	25	empty

Compared structures

7S24 · Crystal structure of the Na+/H+ antiporter NhaA at pH 6.5 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q53YW7
Elsewhere: RCSB PDB 7S24 · PDBe 7S24 · UniProt Q53YW7

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