MolNFT v1 · #187105 · protein
Crystal structure of cavia porecellus (guinea pig) importin-alpha 1 in cargo-free state
7S1E · Importin subunit alpha: “Crystal structure of cavia porecellus (guinea pig) importin-alpha 1 in cargo-free state”. X-ray diffraction, 4 pockets (best druggability 0.69). MolNFT v1 #187105 on GenesisL1: 3D structure, binding sites…
- PDB
- 7S1E
- Type
- protein
- Length
- 845 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin subunit alpha
- UniProt
- H0VVB1
- Pockets
- 4 · best druggability 0.69
Structure
x-ray diffraction · 2 distinct chains · 74% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Importin subunit alpha | protein | 422 | 74% helix, 0% strand | H0VVB1 |
| B | Importin subunit alpha | protein | 423 | 74% helix, 0% strand | H0VVB1 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 788 | 0.69 | 0.76 | 80 | empty |
| 2 | 302 | 0.59 | 0.77 | 35 | empty |
| 3 | 70 | 0.42 | 0.80 | 12 | empty |
| 4 | 62 | 0.30 | 0.75 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 521 Ų buried · 2 hydrogen bonds · protein-protein
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt H0VVB1
- Elsewhere: RCSB PDB 7S1E · PDBe 7S1E · UniProt H0VVB1
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