MolNFT v1 · #187093 · protein
FAB352 in complex with the C-terminal alphatsr domain of P. falciparum
7S0X · FAB352 light chain: “FAB352 in complex with the C-terminal alphatsr domain of P. falciparum”. X-ray diffraction, 10 pockets (best druggability 0.66). MolNFT v1 #187093 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7S0X
- Type
- protein
- Length
- 981 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- FAB352 light chain; FAB352 heavy chain; Circumsporozoite protein
- UniProt
- Q7K740
- Pockets
- 10 · best druggability 0.66
Structure
x-ray diffraction · 4 distinct chains · 8% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | FAB352 light chain | protein | 209 | 8% helix, 48% strand | — |
| H, C | FAB352 heavy chain | protein | 221 | 4% helix, 52% strand | — |
| D | FAB352 light chain | protein | 208 | 8% helix, 49% strand | — |
| E, F | Circumsporozoite protein | protein | 61 | 21% helix, 23% strand | Q7K740 |
Pockets
10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 515 | 0.66 | 0.77 | 60 | empty |
| 2 | 403 | 0.63 | 0.78 | 60 | empty |
| 3 | 227 | 0.60 | 0.80 | 28 | empty |
| 4 | 227 | 0.47 | 0.74 | 33 | empty |
| 5 | 125 | 0.39 | 0.74 | 30 | empty |
Interfaces
8 interfaces between chains.
- D–C · 1761 Ų buried · 19 hydrogen bonds · protein-protein
- L–H · 1752 Ų buried · 17 hydrogen bonds · protein-protein
- H–E · 562 Ų buried · 9 hydrogen bonds · protein-protein
- C–F · 559 Ų buried · 10 hydrogen bonds · protein-protein
- L–D · 405 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide (disulfide).
Compared structures
- 7S0X · Fab352 in complex with the C-terminal alphaTSR domain of P. falciparum · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7K740
- Elsewhere: RCSB PDB 7S0X · PDBe 7S0X · UniProt Q7K740
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.