MolNFT v1 · #187068 · protein + RNA
Crystal structure of fbf-2 in complex with lst-1 site a peptide and fbe RNA
7S02 · Fem-3 mRNA-binding factor 2: “Crystal structure of fbf-2 in complex with lst-1 site a peptide and fbe RNA”. X-ray diffraction, 1 pocket (best druggability 0.36). MolNFT v1 #187068 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7S02
- Type
- protein + RNA
- Length
- 416 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fem-3 mRNA-binding factor 2; Fbe RNA; Lateral signaling target
- UniProt
- Q09312, P91820
- Pockets
- 1 · best druggability 0.36
Structure
x-ray diffraction · 3 distinct chains · 69% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fem-3 mRNA-binding factor 2 | protein | 397 | 71% helix, 1% strand | Q09312 |
| B | Fbe RNA | rna | 8 | — | — |
| C | Lateral signaling target | protein | 11 | 0% helix, 9% strand | P91820 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 54 | 0.36 | 0.79 | 17 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1176 Ų buried · 43 hydrogen bonds · protein-nucleic
- A–C · 645 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 7S02 · Crystal structure of FBF-2 in complex with LST-1 site A peptide and FBE RNA · the same entry in another collection · chain A against A, TM-score 1.00
- Q09312 · AlphaFold monomer V2.0 prediction for fem-3 mRNA-binding factor 2 (Q09312) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q09312
- Every structure of UniProt P91820
- Elsewhere: RCSB PDB 7S02 · PDBe 7S02 · UniProt Q09312 · UniProt P91820
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