MolNFT v1 · #187058 · protein
Cryo-EM structure of the SARS-cov-2 HR1HR2 fusion core complex with D936Y mutation
7RZR · SARS-cov-2 HR1 D936Y linked to a SCAFFOLD,SPIKE protein S2': “Cryo-EM structure of the SARS-cov-2 HR1HR2 fusion core complex with D936Y mutation”. Electron microscopy, 1 pocket (best druggability 0.71). MolNFT v1 #187058 on…
- PDB
- 7RZR
- Type
- protein
- Length
- 324 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SARS-cov-2 HR1 D936Y linked to a SCAFFOLD,SPIKE protein S2'; Spike protein S2'
- UniProt
- P0DTC2
- Pockets
- 1 · best druggability 0.71
Structure
electron microscopy · 2 distinct chains · 80% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | SARS-cov-2 HR1 D936Y linked to a SCAFFOLD,SPIKE protein S2' | protein | 71 | 97% helix, 0% strand | P0DTC2 |
| D, E, F | Spike protein S2' | protein | 37 | 46% helix, 0% strand | P0DTC2 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 50 | 0.71 | 0.99 | 17 | empty |
Interfaces
9 interfaces between chains.
- B–D · 1190 Ų buried · 15 hydrogen bonds · protein-protein
- A–D · 1188 Ų buried · 14 hydrogen bonds · protein-protein
- C–E · 1186 Ų buried · 15 hydrogen bonds · protein-protein
- B–E · 1185 Ų buried · 14 hydrogen bonds · protein-protein
- C–F · 1184 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 7RZR · Cryo-EM structure of the SARS-CoV-2 HR1HR2 fusion core complex with D936Y mutation · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0DTC2
- Elsewhere: RCSB PDB 7RZR · PDBe 7RZR · UniProt P0DTC2
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