MolNFT v1 · #187033 · protein
Anti-HIV neutralizing antibody AB1573 Fab isolated from sequentially immunized macaques
7RYV · AB1573 Fab heavy chain: “Anti-HIV neutralizing antibody AB1573 Fab isolated from sequentially immunized macaques”. X-ray diffraction, 20 pockets (best druggability 0.62). MolNFT v1 #187033 on GenesisL1: 3D structure, binding sites…
- PDB
- 7RYV
- Type
- protein
- Length
- 1,725 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- AB1573 Fab heavy chain; AB1573 Fab light chain
- Pockets
- 20 · best druggability 0.62
Structure
x-ray diffraction · 6 distinct chains · 6% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| E | AB1573 Fab heavy chain | protein | 218 | 8% helix, 51% strand | — |
| F, Q | AB1573 Fab light chain | protein | 213 | 6% helix, 51% strand | — |
| H | AB1573 Fab heavy chain | protein | 220 | 6% helix, 50% strand | — |
| I, P | AB1573 Fab heavy chain | protein | 219 | 6% helix, 52% strand | — |
| J | AB1573 Fab light chain | protein | 211 | 7% helix, 52% strand | — |
| L | AB1573 Fab light chain | protein | 212 | 6% helix, 51% strand | — |
Pockets
20 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 517 | 0.62 | 0.75 | 66 | empty |
| 2 | 567 | 0.61 | 0.74 | 50 | empty |
| 3 | 75 | 0.43 | 0.81 | 17 | empty |
| 4 | 146 | 0.41 | 0.74 | 30 | empty |
| 5 | 71 | 0.40 | 0.80 | 16 | empty |
Interfaces
12 interfaces between chains.
- E–F · 1718 Ų buried · 13 hydrogen bonds · protein-protein
- P–Q · 1659 Ų buried · 15 hydrogen bonds · protein-protein
- H–L · 1653 Ų buried · 12 hydrogen bonds · protein-protein
- I–J · 1615 Ų buried · 15 hydrogen bonds · protein-protein
- E–H · 315 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 15 disulfide (disulfide).
Compared structures
- 7RYV · Anti-HIV neutralizing antibody Ab1573 Fab isolated from sequentially immunized macaques · the same entry in another collection · chain E against E, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7RYV · PDBe 7RYV
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.