MolNFT v1 · #187032 · protein
Anti-HIV neutralizing antibody AB1303 Fab isolated from sequentially immunized mcaques
7RYU · AB1303 Fab heavy chain: “Anti-HIV neutralizing antibody AB1303 Fab isolated from sequentially immunized mcaques”. X-ray diffraction, 4 pockets (best druggability 0.55). MolNFT v1 #187032 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7RYU
- Type
- protein
- Length
- 440 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- AB1303 Fab heavy chain; AB1303 Fab light chain
- Pockets
- 4 · best druggability 0.55
Structure
x-ray diffraction · 2 distinct chains · 9% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | AB1303 Fab heavy chain | protein | 225 | 10% helix, 51% strand | — |
| L | AB1303 Fab light chain | protein | 215 | 8% helix, 53% strand | — |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 309 | 0.55 | 0.76 | 42 | empty |
| 2 | 149 | 0.50 | 0.79 | 32 | empty |
| 3 | 88 | 0.42 | 0.79 | 18 | empty |
| 4 | 118 | 0.39 | 0.74 | 20 | empty |
Interfaces
1 interface between chains.
- H–L · 2021 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 7RYU · Anti-HIV neutralizing antibody Ab1303 Fab isolated from sequentially immunized mcaques · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7RYU · PDBe 7RYU
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