MolNFT v1 · #186919 · protein

Crystal structure of the octameric form of RV3208A

7RUS · DUF3107 domain-containing protein: “Crystal structure of the octameric form of RV3208A”. X-ray diffraction, 2 pockets (best druggability 0.72). MolNFT v1 #186919 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7RUS
Type: protein
Length: 525 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DUF3107 domain-containing protein
UniProt: A0A3E0USZ9
Pockets: 2 · best druggability 0.72

Structure

x-ray diffraction · 2 distinct chains · 26% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C, N, e, g	DUF3107 domain-containing protein	protein	66	26% helix, 38% strand	A0A3E0USZ9
B, D, P	DUF3107 domain-containing protein	protein	65	26% helix, 38% strand	A0A3E0USZ9

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	858	0.72	0.77	94	empty
2	238	0.52	0.76	23	empty

Interfaces

17 interfaces between chains.

N–P · 920 Å² buried · 22 hydrogen bonds · protein-protein
A–D · 905 Å² buried · 16 hydrogen bonds · protein-protein
A–B · 887 Å² buried · 15 hydrogen bonds · protein-protein
C–D · 886 Å² buried · 16 hydrogen bonds · protein-protein
e–g · 881 Å² buried · 16 hydrogen bonds · protein-protein

Compared structures

7RUS · Crystal structure of the octameric form of Rv3208A · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A3E0USZ9
Elsewhere: RCSB PDB 7RUS · PDBe 7RUS · UniProt A0A3E0USZ9

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