MolNFT v1 · #186913 · protein

Endolysin from escherichia COLI O157:H7 phage FTEBC1, LYST84

7RUM: “Endolysin from escherichia COLI O157:H7 phage FTEBC1, LYST84”. X-ray diffraction, 4 pockets (best druggability 0.65). MolNFT v1 #186913 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7RUM
Type: protein
Length: 524 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Endolysin
UniProt: A0A7S9SQH6
Pockets: 4 · best druggability 0.65

Structure

x-ray diffraction · 2 distinct chains · 58% helix, 6% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Endolysin	protein	263	57% helix, 5% strand	A0A7S9SQH6
B	Endolysin	protein	261	59% helix, 6% strand	A0A7S9SQH6

Ligands and binding sites

GOL · Glycerol · additive · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	181	0.65	0.85	31	GOL
2	144	0.56	0.82	20	GOL
3	52	0.29	0.74	12	empty
4	67	0.28	0.73	18	empty

Interfaces

1 interface between chains.

A–B · 188 Å² buried · 3 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

7RUM · Endolysin from Escherichia coli O157:H7 phage FTEbC1, LysT84 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A7S9SQH6
Elsewhere: RCSB PDB 7RUM · PDBe 7RUM · UniProt A0A7S9SQH6

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