MolNFT v1 · #186805 · protein

Structure of pfcsp npnv binding antibody L9

7RQP · L9 heavy chain: “Structure of pfcsp npnv binding antibody L9”. X-ray diffraction, 4 pockets (best druggability 0.62). MolNFT v1 #186805 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7RQP
Type: protein
Length: 425 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: L9 heavy chain; L9 kappa chain
Pockets: 4 · best druggability 0.62

Structure

x-ray diffraction · 2 distinct chains · 5% helix, 47% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	L9 heavy chain	protein	213	3% helix, 45% strand	—
B	L9 kappa chain	protein	212	6% helix, 50% strand	—

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	592	0.62	0.74	56	empty
2	67	0.39	0.79	17	empty
3	99	0.35	0.74	21	empty
4	68	0.28	0.73	15	empty

Interfaces

1 interface between chains.

A–B · 1618 Å² buried · 11 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

7RQP · Structure of PfCSP NPNV binding antibody L9 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 7RQP · PDBe 7RQP

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