Crystal structure of human bromodomain containing protein 4 (BRD4) in complex with BCLTF1

Structure

x-ray diffraction · 2 distinct chains · 51% helix, 0% strand (DSSP).

Ligands and binding sites

• NA · Sodium ion · metal · chains A
• EDO · 1,2-ethanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 331 Ų buried · 1 hydrogen bond · protein-protein

Modifications

Observed in the structure: 1 modified (acetylation).

Compared structures

• 7RJR · Crystal structure of human Bromodomain containing protein 4 (BRD4) in complex with BCLTF1 · the same entry in another collection · chain A against A, TM-score 1.00
• O60885 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 4 (O60885) · a predicted model of the same protein · chain A against A, TM-score 0.97
• Q9NYF8 · AlphaFold monomer V2.0 prediction for BCL-2-associated transcription factor 1 (Q9NYF8) · a predicted model of the same protein · chain B against A, TM-score 0.76

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt O60885
• Every structure of UniProt Q9NYF8
• Elsewhere: RCSB PDB 7RJR · PDBe 7RJR · UniProt O60885 · UniProt Q9NYF8