Crystal structure of human bromodomain containing protein 4 (BRD4) in complex with ILF3

Structure

x-ray diffraction · 2 distinct chains · 51% helix, 0% strand (DSSP).

Ligands and binding sites

• NA · Sodium ion · metal · 5 copies · chains A
• CL · Chloride ion · ion · 3 copies · chains A, B
• EDO · 1,2-ethanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 442 Ų buried · 3 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 modified (acetylation).

Compared structures

• 7RJQ · Crystal structure of human Bromodomain containing protein 4 (BRD4) in complex with ILF3 · the same entry in another collection · chain A against A, TM-score 1.00
• O60885 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 4 (O60885) · a predicted model of the same protein · chain A against A, TM-score 0.96
• Q12906 · AlphaFold monomer V2.0 prediction for interleukin enhancer-binding factor 3 (Q12906) · a predicted model of the same protein · chain B against A, TM-score 0.49

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt O60885
• Every structure of UniProt Q12906
• Elsewhere: RCSB PDB 7RJQ · PDBe 7RJQ · UniProt O60885 · UniProt Q12906