Crystal structure of human bromodomain containing protein 4 (BRD4) in complex with hnrnpk

Structure

x-ray diffraction · 2 distinct chains · 50% helix, 0% strand (DSSP).

Ligands and binding sites

• NA · Sodium ion · metal · chains A, B
• GOL · Glycerol · additive · 2 copies · chains A
• ACT · Acetate ion · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 642 Ų buried · 4 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 modified (acetylation).

Compared structures

• 7RJO · Crystal structure of human Bromodomain containing protein 4 (BRD4) in complex with hnRNPK · the same entry in another collection · chain A against A, TM-score 1.00
• O60885 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 4 (O60885) · a predicted model of the same protein · chain A against A, TM-score 0.96
• P61978 · AlphaFold monomer V2.0 prediction for heterogeneous nuclear ribonucleoprotein K (P61978) · a predicted model of the same protein · chain B against A, TM-score 0.32

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt O60885
• Every structure of UniProt P61978
• Elsewhere: RCSB PDB 7RJO · PDBe 7RJO · UniProt O60885 · UniProt P61978