MolNFT v1 · #186588 · protein
Human pxr lbd bound to GSK001
7RIV · Isoform 1C of nuclear receptor subfamily 1 group I member 2: “Human pxr lbd bound to GSK001”. X-ray diffraction, 1 ligand (P06), 2 pockets (best druggability 0.85). MolNFT v1 #186588 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7RIV
- Type
- protein
- Length
- 270 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Isoform 1C of nuclear receptor subfamily 1 group I member 2
- UniProt
- O75469
- Ligands
- P06
- Pockets
- 2 · best druggability 0.85
Structure
x-ray diffraction · 1 distinct chain · 61% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Isoform 1C of nuclear receptor subfamily 1 group I member 2 | protein | 270 | 61% helix, 8% strand | O75469 |
Ligands and binding sites
- P06 · Dabrafenib · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 505 | 0.85 | 0.91 | 45 | P06 |
| 2 | 88 | 0.35 | 0.74 | 16 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75469
- Elsewhere: RCSB PDB 7RIV · PDBe 7RIV · UniProt O75469
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