MolNFT v1 · #186561 · protein + DNA
Cryo-EM structure of precleavage cre tetrameric complex
7RHX · Recombinase cre: “Cryo-EM structure of precleavage cre tetrameric complex”. Electron microscopy, 20 pockets (best druggability 0.87). MolNFT v1 #186561 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7RHX
- Type
- protein + DNA
- Length
- 1,456 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Recombinase cre; DNA (42-mer)
- UniProt
- P06956
- Pockets
- 20 · best druggability 0.87
Structure
electron microscopy · 3 distinct chains · 58% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, G, H | Recombinase cre | protein | 322 | 58% helix, 4% strand | P06956 |
| C, E | DNA (42-mer) | dna | 42 | — | — |
| D, F | DNA (42-mer) | dna | 42 | — | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1025 | 0.87 | 0.89 | 83 | empty |
| 2 | 1095 | 0.87 | 0.88 | 95 | empty |
| 3 | 784 | 0.75 | 0.80 | 59 | empty |
| 4 | 787 | 0.74 | 0.79 | 63 | empty |
| 5 | 402 | 0.73 | 0.84 | 48 | empty |
Interfaces
18 interfaces between chains.
- C–D · 2002 Ų buried · 126 hydrogen bonds · nucleic-nucleic
- E–F · 1996 Ų buried · 131 hydrogen bonds · nucleic-nucleic
- G–H · 1953 Ų buried · 14 hydrogen bonds · protein-protein
- A–B · 1912 Ų buried · 15 hydrogen bonds · protein-protein
- A–H · 1605 Ų buried · 22 hydrogen bonds · protein-protein
Compared structures
- 7RHX · Cryo-EM structure of precleavage Cre tetrameric complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06956
- Elsewhere: RCSB PDB 7RHX · PDBe 7RHX · UniProt P06956
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