MolNFT v1 · #186488 · protein
Semet tailspike protein 4 (TSP4) phage CBA120, residues 1-335, obtained in the presence of LISO4
7RFO: “Semet tailspike protein 4 (TSP4) phage CBA120, residues 1-335, obtained in the presence of LISO4”. X-ray diffraction, 12 pockets (best druggability 0.84). MolNFT v1 #186488 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7RFO
- Type
- protein
- Length
- 983 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tailspike protein
- UniProt
- G3M192
- Pockets
- 12 · best druggability 0.84
Structure
x-ray diffraction · 3 distinct chains · 1% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tailspike protein | protein | 329 | 1% helix, 41% strand | G3M192 |
| B | Tailspike protein | protein | 330 | 1% helix, 43% strand | G3M192 |
| C | Tailspike protein | protein | 324 | 1% helix, 43% strand | G3M192 |
Pockets
12 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1171 | 0.84 | 0.85 | 109 | empty |
| 2 | 1194 | 0.75 | 0.78 | 108 | empty |
| 3 | 101 | 0.72 | 0.94 | 25 | empty |
| 4 | 408 | 0.66 | 0.79 | 47 | empty |
| 5 | 328 | 0.61 | 0.78 | 36 | empty |
Interfaces
3 interfaces between chains.
- B–C · 3184 Ų buried · 48 hydrogen bonds · protein-protein
- A–B · 3055 Ų buried · 52 hydrogen bonds · protein-protein
- A–C · 3038 Ų buried · 51 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 16 modified (engineered).
Compared structures
- 7RFO · SeMet Tailspike protein 4 (TSP4) phage CBA120, residues 1-335, obtained in the presence… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G3M192
- Elsewhere: RCSB PDB 7RFO · PDBe 7RFO · UniProt G3M192
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