MolNFT v1 · #186330 · protein
ANCAR1-rev - progesterone - TIF2
7RAF · Ancestral androgen receptor: “ANCAR1-rev - progesterone - TIF2”. X-ray diffraction, 1 ligand (STR), 2 pockets (best druggability 0.84). MolNFT v1 #186330 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7RAF
- Type
- protein
- Length
- 258 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ancestral androgen receptor; Transcriptional MEDIATOR/INTERMEDIARY factor 2
- Ligands
- STR
- Pockets
- 2 · best druggability 0.84
Structure
x-ray diffraction · 2 distinct chains · 70% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ancestral androgen receptor | protein | 246 | 70% helix, 5% strand | — |
| D | Transcriptional MEDIATOR/INTERMEDIARY factor 2 | protein | 12 | 58% helix, 0% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 196 | 0.84 | 0.97 | 23 | STR |
| 2 | 138 | 0.63 | 0.85 | 21 | GOL |
Interfaces
1 interface between chains.
- A–D · 564 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 7RAF · AncAR1-Rev - progesterone - Tif2 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7RAF · PDBe 7RAF
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