MolNFT v1 · #186313 · protein

Structure of PIK3CA with covalent inhibitor 19

7R9V: “Structure of PIK3CA with covalent inhibitor 19”. X-ray diffraction, 1 ligand (2Q7). MolNFT v1 #186313 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7R9V
Type: protein
Length: 855 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P42336
Ligands: 2Q7

Structure

x-ray diffraction · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	855	—	P42336

Ligands and binding sites

2Q7 · N-[2-(4-{4-[2-amino-4-(difluoromethyl)pyrimidin-5-yl]-6-(morpholin-4-yl)-1,3,5-triazin-2-yl}piperazin-1-yl)-2-oxoethyl]-1-(prop-2-enoyl)piperidine-4-carboxamide · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7R9V · Structure of PIK3CA with covalent inhibitor 19 · the same entry in another collection · chain A against A, TM-score 1.00
P42336 · AlphaFold monomer V2.0 prediction for phosphatidylinositol 4,5-bisphosphate 3-kinase… · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P42336
Elsewhere: RCSB PDB 7R9V · PDBe 7R9V · UniProt P42336

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