MolNFT v1 · #186074 · protein

Spinach 20S proteasome

7QVE · Proteasome subunit alpha type: “Spinach 20S proteasome”. Electron microscopy, 20 pockets (best druggability 0.82). MolNFT v1 #186074 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7QVE
Type: protein
Length: 6,256 residues
Chains: 28
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Proteasome subunit alpha type; Proteasome subunit alpha type-3; Proteasome subunit beta…
EC: 3.4.25.1
UniProt: A0A0K9QA79, A0A0K9RH20, A0A0K9S0K6, A0A0K9RE77, A0A0K9RGG6, O24362, A0A0K9R8Z8, A0A0K9S2G1, A0A0K9S3A8, A0A0K9S024, A0A0K9QSM9, O24361, A0A0K9RTN8, A0A0K9RED8
Pockets: 20 · best druggability 0.82

Structure

electron microscopy · 14 distinct chains · 35% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
i, C	Proteasome subunit alpha type	protein	229	36% helix, 26% strand	A0A0K9QA79
j, D	Proteasome subunit alpha type	protein	249	41% helix, 23% strand	A0A0K9RH20
k, E	Proteasome subunit alpha type	protein	240	41% helix, 23% strand	A0A0K9S0K6
l, F	Proteasome subunit alpha type	protein	230	34% helix, 23% strand	A0A0K9RE77
m, G	Proteasome subunit alpha type	protein	231	36% helix, 25% strand	A0A0K9RGG6
n, X	Proteasome subunit alpha type-3	protein	239	38% helix, 26% strand	O24362
B, h	Proteasome subunit alpha type	protein	238	39% helix, 26% strand	A0A0K9R8Z8
o, a	Proteasome subunit beta	protein	212	34% helix, 27% strand	A0A0K9S2G1
p, b	Proteasome subunit beta	protein	220	29% helix, 31% strand	A0A0K9S3A8
q, c	Proteasome subunit beta	protein	203	32% helix, 29% strand	A0A0K9S024
r, d	Proteasome subunit beta	protein	196	35% helix, 31% strand	A0A0K9QSM9
s, e	Proteasome subunit beta type-5 (EC 3.4.25.1)	protein	203	37% helix, 33% strand	O24361
t, f	Proteasome subunit beta	protein	217	30% helix, 26% strand	A0A0K9RTN8
u, g	Proteasome subunit beta	protein	221	32% helix, 30% strand	A0A0K9RED8

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	280	0.82	0.93	38	empty
2	281	0.82	0.93	38	empty
3	1058	0.82	0.83	115	empty
4	1032	0.82	0.83	116	empty
5	897	0.80	0.83	81	empty

Interfaces

89 interfaces between chains.

u–a · 1925 Å² buried · 25 hydrogen bonds · protein-protein
o–g · 1903 Å² buried · 24 hydrogen bonds · protein-protein
D–E · 1566 Å² buried · 23 hydrogen bonds · protein-protein
j–k · 1512 Å² buried · 16 hydrogen bonds · protein-protein
m–n · 1480 Å² buried · 21 hydrogen bonds · protein-protein

Compared structures

7QVE · Spinach 20S proteasome · the same entry in another collection · chain F against F, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A0K9QA79
Every structure of UniProt A0A0K9RH20
Every structure of UniProt A0A0K9S0K6
Every structure of UniProt A0A0K9RE77
Every structure of UniProt A0A0K9RGG6
Every structure of UniProt O24362
Every structure of UniProt A0A0K9R8Z8
Every structure of UniProt A0A0K9S2G1
Every structure of UniProt A0A0K9S3A8
Every structure of UniProt A0A0K9S024
Every structure of UniProt A0A0K9QSM9
Every structure of UniProt O24361
Every structure of UniProt A0A0K9RTN8
Every structure of UniProt A0A0K9RED8
Elsewhere: RCSB PDB 7QVE · PDBe 7QVE · UniProt A0A0K9QA79 · UniProt A0A0K9RH20 · UniProt A0A0K9S0K6 · UniProt A0A0K9RE77 · UniProt A0A0K9RGG6 · UniProt O24362 · UniProt A0A0K9R8Z8 · UniProt A0A0K9S2G1 · UniProt A0A0K9S3A8 · UniProt A0A0K9S024 · UniProt A0A0K9QSM9 · UniProt O24361 · UniProt A0A0K9RTN8 · UniProt A0A0K9RED8

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