MolNFT v1 · #186051 · protein
Structural biology of the NS1 avian influenza protein subversion on the scribble cell polarity module
7QTO · Protein scribble homolog: “Structural biology of the NS1 avian influenza protein subversion on the scribble cell polarity module”. X-ray diffraction, 1 pocket (best druggability 0.51). MolNFT v1 #186051 on GenesisL1: 3D structure…
- PDB
- 7QTO
- Type
- protein
- Length
- 196 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein scribble homolog; Non-structural protein 1
- UniProt
- Q14160, Q6DP93
- Pockets
- 1 · best druggability 0.51
Structure
x-ray diffraction · 4 distinct chains · 13% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein scribble homolog | protein | 88 | 14% helix, 39% strand | Q14160 |
| B | Protein scribble homolog | protein | 95 | 14% helix, 32% strand | Q14160 |
| C | Non-structural protein 1 | protein | 8 | 0% helix, 13% strand | Q6DP93 |
| D | Non-structural protein 1 | protein | 5 | 0% helix, 40% strand | Q6DP93 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 93 | 0.51 | 0.83 | 24 | empty |
Interfaces
6 interfaces between chains.
- B–C · 489 Ų buried · 5 hydrogen bonds · protein-protein
- A–D · 353 Ų buried · 9 hydrogen bonds · protein-protein
- B–D · 176 Ų buried · 1 hydrogen bond · protein-protein
- A–C · 161 Ų buried · 0 hydrogen bonds · protein-protein
- A–B · 123 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 7QTO · Structural biology of the NS1 avian influenza protein subversion on the Scribble cell… · the same entry in another collection · chain A against A, TM-score 1.00
- Q14160 · AlphaFold monomer V2.0 prediction for protein scribble homolog (Q14160) · a predicted model of the same protein · chain A against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14160
- Every structure of UniProt Q6DP93
- Elsewhere: RCSB PDB 7QTO · PDBe 7QTO · UniProt Q14160 · UniProt Q6DP93
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.