MolNFT v1 · #186032 · protein
Structural basis on the interaction of scribble PDZ domains with the tick born encephalitis virus (tbev) NS5 protein
7QSA · Protein scribble homolog: “Structural basis on the interaction of scribble PDZ domains with the tick born encephalitis virus (tbev) NS5…”. X-ray diffraction, 1 pocket (best druggability 0.67). MolNFT v1 #186032 on GenesisL1: 3D…
- PDB
- 7QSA
- Type
- protein
- Length
- 169 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein scribble homolog; RNA-directed RNA polymerase NS5
- EC
- 2.1.1.56, 2.1.1.57, 2.7.7.48
- UniProt
- Q14160, Q01299
- Pockets
- 1 · best druggability 0.67
Structure
x-ray diffraction · 3 distinct chains · 13% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein scribble homolog | protein | 85 | 16% helix, 35% strand | Q14160 |
| B | Protein scribble homolog | protein | 78 | 10% helix, 38% strand | Q14160 |
| C | RNA-directed RNA polymerase NS5 (EC 2.1.1.56, 2.1.1.57, 2.7.7.48) | protein | 6 | 0% helix, 67% strand | Q01299 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 165 | 0.67 | 0.87 | 26 | empty |
Interfaces
3 interfaces between chains.
- A–B · 505 Ų buried · 1 hydrogen bond · protein-protein
- A–C · 440 Ų buried · 11 hydrogen bonds · protein-protein
- B–C · 386 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 7QSA · Structural basis on the interaction of Scribble PDZ domains with the Tick Born… · the same entry in another collection · chain A against A, TM-score 1.00
- Q14160 · AlphaFold monomer V2.0 prediction for protein scribble homolog (Q14160) · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14160
- Every structure of UniProt Q01299
- Elsewhere: RCSB PDB 7QSA · PDBe 7QSA · UniProt Q14160 · UniProt Q01299
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