MolNFT v1 · #185870 · protein

X-ray structure of apo-elenrmt in complex with two nanobodies at 4.1A

7QJI · Divalent metal cation transporter: “X-ray structure of apo-elenrmt in complex with two nanobodies at 4.1A”. X-ray diffraction, 11 pockets (best druggability 0.74). MolNFT v1 #185870 on GenesisL1: 3D structure, binding sites and…

PDB: 7QJI
Type: protein
Length: 1,272 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Divalent metal cation transporter; Elen-nanobody-complex
UniProt: A0A369N1S1
Pockets: 11 · best druggability 0.74

Structure

x-ray diffraction · 3 distinct chains · 50% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, E	Divalent metal cation transporter	protein	398	77% helix, 0% strand	A0A369N1S1
C, F	Elen-nanobody-complex	protein	117	0% helix, 38% strand	—
B, G	Elen-nanobody-complex	protein	121	7% helix, 30% strand	—

Pockets

11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	563	0.74	0.81	47	empty
2	570	0.74	0.81	47	empty
3	205	0.66	0.85	30	empty
4	228	0.65	0.84	32	empty
5	265	0.50	0.74	41	empty

Interfaces

6 interfaces between chains.

E–F · 675 Å² buried · 14 hydrogen bonds · protein-protein
A–C · 657 Å² buried · 12 hydrogen bonds · protein-protein
E–G · 596 Å² buried · 4 hydrogen bonds · protein-protein
A–B · 590 Å² buried · 4 hydrogen bonds · protein-protein
C–B · 183 Å² buried · 1 hydrogen bond · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

7QJI · X-Ray Structure of apo-EleNRMT in complex with two Nanobodies at 4.1A · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A369N1S1
Elsewhere: RCSB PDB 7QJI · PDBe 7QJI · UniProt A0A369N1S1

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