MolNFT v1 · #185846 · protein
Complex of the yersinia enterocolitica type III secretion proteins yscx and yscy
7QIH · Chaperone protein yscy: “Complex of the yersinia enterocolitica type III secretion proteins yscx and yscy”. X-ray diffraction, 5 pockets (best druggability 0.60). MolNFT v1 #185846 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7QIH
- Type
- protein
- Length
- 357 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chaperone protein yscy; Yop proteins translocation protein X
- UniProt
- P0C2N2, P0C2N4
- Pockets
- 5 · best druggability 0.60
Structure
x-ray diffraction · 4 distinct chains · 76% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chaperone protein yscy | protein | 111 | 76% helix, 0% strand | P0C2N2 |
| B | Yop proteins translocation protein X | protein | 71 | 76% helix, 0% strand | P0C2N4 |
| C | Chaperone protein yscy | protein | 110 | 76% helix, 0% strand | P0C2N2 |
| D | Yop proteins translocation protein X | protein | 65 | 77% helix, 0% strand | P0C2N4 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 337 | 0.60 | 0.77 | 31 | empty |
| 2 | 195 | 0.53 | 0.78 | 28 | empty |
| 3 | 101 | 0.48 | 0.81 | 21 | empty |
| 4 | 80 | 0.40 | 0.78 | 16 | empty |
| 5 | 100 | 0.36 | 0.75 | 20 | empty |
Interfaces
6 interfaces between chains.
- A–B · 1559 Ų buried · 4 hydrogen bonds · protein-protein
- C–D · 1528 Ų buried · 8 hydrogen bonds · protein-protein
- A–D · 586 Ų buried · 8 hydrogen bonds · protein-protein
- B–C · 557 Ų buried · 8 hydrogen bonds · protein-protein
- B–D · 509 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7QIH · Complex of the Yersinia enterocolitica Type III secretion proteins YscX and YscY · the same entry in another collection · chain D against D, TM-score 1.00
- P0C2N2 · AlphaFold monomer V2.0 prediction for chaperone protein yscy (P0C2N2) · a predicted model of the same protein · chain C against A, TM-score 0.96
- P0C2N4 · AlphaFold monomer V2.0 prediction for yop proteins translocation protein X (P0C2N4) · a predicted model of the same protein · chain D against A, TM-score 0.68
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0C2N2
- Every structure of UniProt P0C2N4
- Elsewhere: RCSB PDB 7QIH · PDBe 7QIH · UniProt P0C2N2 · UniProt P0C2N4
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