MolNFT v1 · #185844 · protein

Crystal structure of SARS-cov-2 NSP14 in complex with 7MEGPPPG.

7QIF · Proofreading exoribonuclease NSP14: “Crystal structure of SARS-cov-2 NSP14 in complex with 7MEGPPPG.”. X-ray diffraction, 3 ligands (GTG, ZN, PO4), 8 pockets (best druggability 0.70). MolNFT v1 #185844 on GenesisL1: 3D structure…

PDB: 7QIF
Type: protein
Length: 458 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Proofreading exoribonuclease NSP14
EC: 3.1.13.-
UniProt: P0DTD1
Ligands: GTG, ZN, PO4
Pockets: 8 · best druggability 0.70

Structure

x-ray diffraction · 1 distinct chain · 29% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
D	Proofreading exoribonuclease NSP14 (EC 3.1.13.-)	protein	458	29% helix, 22% strand	P0DTD1

Ligands and binding sites

GTG · 7-methyl-guanosine-5'-triphosphate-5'-guanosine · ligand · chains D
ZN · Zinc ion · metal · 3 copies · chains D
PO4 · Phosphate ion · ion · 2 copies · chains D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	430	0.70	0.81	32	GTG
2	107	0.43	0.78	21	empty
3	52	0.38	0.81	14	empty
4	59	0.35	0.78	21	PO4
5	56	0.33	0.77	19	empty

Compared structures

7QIF · Crystal structure of SARS-CoV-2 NSP14 in complex with 7MeGpppG. · the same entry in another collection · chain D against D, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0DTD1
Elsewhere: RCSB PDB 7QIF · PDBe 7QIF · UniProt P0DTD1

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