MolNFT v1 · #185814 · protein
Crystal structure of SARS-cov-2 NSP14 in the absence of NSP10
7QGI · Proofreading exoribonuclease NSP14: “Crystal structure of SARS-cov-2 NSP14 in the absence of NSP10”. X-ray diffraction, 2 ligands (ZN, PO4), 6 pockets (best druggability 0.68). MolNFT v1 #185814 on GenesisL1: 3D structure, binding…
- PDB
- 7QGI
- Type
- protein
- Length
- 457 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proofreading exoribonuclease NSP14
- EC
- 3.1.13.-
- UniProt
- P0DTD1
- Ligands
- ZN, PO4
- Pockets
- 6 · best druggability 0.68
Structure
x-ray diffraction · 1 distinct chain · 28% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| D | Proofreading exoribonuclease NSP14 (EC 3.1.13.-) | protein | 457 | 28% helix, 21% strand | P0DTD1 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 394 | 0.68 | 0.81 | 32 | empty |
| 2 | 181 | 0.47 | 0.75 | 31 | empty |
| 3 | 64 | 0.36 | 0.78 | 20 | PO4 |
| 4 | 53 | 0.30 | 0.76 | 10 | PO4 |
| 5 | 57 | 0.29 | 0.75 | 13 | empty |
Compared structures
- 7QGI · Crystal structure of SARS-CoV-2 NSP14 in the absence of NSP10 · the same entry in another collection · chain D against D, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0DTD1
- Elsewhere: RCSB PDB 7QGI · PDBe 7QGI · UniProt P0DTD1
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