MolNFT v1 · #185612 · protein
Structure of the human cplane complex
7Q3D · Wd repeat-containing and planar cell polarity effector…: “Structure of the human cplane complex”. Electron microscopy, 19 pockets (best druggability 0.78). MolNFT v1 #185612 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7Q3D
- Type
- protein
- Length
- 1,391 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Wd repeat-containing and planar cell polarity effector protein fritz homolog; Protein…
- UniProt
- O95876, Q9ULD6, Q9BT04
- Pockets
- 19 · best druggability 0.78
Structure
electron microscopy · 3 distinct chains · 33% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Wd repeat-containing and planar cell polarity effector protein fritz homolog | protein | 545 | 26% helix, 34% strand | O95876 |
| B | Protein inturned | protein | 453 | 40% helix, 25% strand | Q9ULD6 |
| C | Protein fuzzy homolog | protein | 393 | 34% helix, 27% strand | Q9BT04 |
Pockets
19 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 311 | 0.78 | 0.89 | 53 | empty |
| 2 | 1092 | 0.78 | 0.80 | 87 | empty |
| 3 | 1124 | 0.72 | 0.76 | 69 | empty |
| 4 | 95 | 0.69 | 0.92 | 24 | empty |
| 5 | 216 | 0.64 | 0.83 | 43 | empty |
Interfaces
3 interfaces between chains.
- A–B · 2763 Ų buried · 29 hydrogen bonds · protein-protein
- B–C · 2048 Ų buried · 28 hydrogen bonds · protein-protein
- A–C · 503 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 7Q3D · Structure of the human CPLANE complex · the same entry in another collection · chain A against A, TM-score 1.00
- O95876 · AlphaFold monomer V2.0 prediction for wd repeat-containing and planar cell polarity… · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q9BT04 · AlphaFold monomer V2.0 prediction for protein fuzzy homolog (Q9BT04) · a predicted model of the same protein · chain C against A, TM-score 0.96
- Q9ULD6 · AlphaFold monomer V2.0 prediction for protein inturned (Q9ULD6) · a predicted model of the same protein · chain B against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O95876
- Every structure of UniProt Q9ULD6
- Every structure of UniProt Q9BT04
- Elsewhere: RCSB PDB 7Q3D · PDBe 7Q3D · UniProt O95876 · UniProt Q9ULD6 · UniProt Q9BT04
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