Mouse interleukin-12 subunit beta - P80 homodimer in space group P21 crystal form 2

Structure

x-ray diffraction · 2 distinct chains · 2% helix, 53% strand (DSSP).

Ligands and binding sites

• MAN · alpha-D-mannopyranose · sugar · 7 copies · chains A, B
• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 4 copies · chains A, B
• BMA · beta-D-mannopyranose · sugar · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 315 Ų buried · 3 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 12 disulfide, 2 glycan (disulfide, N-glycosylation).

Compared structures

• 7PUR · mouse Interleukin-12 subunit beta - p80 homodimer in space group P21 crystal form 2 · the same entry in another collection · chain A against A, TM-score 1.00
• P43432 · AlphaFold monomer V2.0 prediction for interleukin-12 subunit beta (P43432) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P43432
• Elsewhere: RCSB PDB 7PUR · PDBe 7PUR · UniProt P43432