MolNFT v1 · #185269 · protein

Apo HSPEPT1 in the outward facing open conformation

7PN1 · Solute carrier family 15 member 1: “Apo HSPEPT1 in the outward facing open conformation”. Electron microscopy, 8 pockets (best druggability 0.77). MolNFT v1 #185269 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7PN1
Type: protein
Length: 657 residues
Chains: 1
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Solute carrier family 15 member 1
UniProt: P46059
Pockets: 8 · best druggability 0.77

Structure

electron microscopy · 1 distinct chain · 58% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Solute carrier family 15 member 1	protein	657	58% helix, 14% strand	P46059

Pockets

8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1070	0.77	0.79	71	empty
2	247	0.59	0.80	43	empty
3	178	0.54	0.79	31	empty
4	97	0.36	0.74	18	empty
5	87	0.35	0.74	22	empty

Compared structures

7PN1 · Apo HsPepT1 in the outward facing open conformation · the same entry in another collection · chain A against A, TM-score 1.00
P46059 · AlphaFold monomer V2.0 prediction for solute carrier family 15 member 1 (P46059) · a predicted model of the same protein · chain A against A, TM-score 0.82

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P46059
Elsewhere: RCSB PDB 7PN1 · PDBe 7PN1 · UniProt P46059

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