MolNFT v1 · #185218 · protein

Structure of SARS-cov-2 nucleoprotein in dynamic complex with its viral partner NSP3A

7PKU · 3C-like proteinase: “Structure of SARS-cov-2 nucleoprotein in dynamic complex with its viral partner NSP3A”. Solution nmr, 2 pockets (best druggability 0.54). MolNFT v1 #185218 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 7PKU
Type: protein
Length: 169 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 3C-like proteinase; Nucleoprotein
EC: 3.4.19.12, 3.4.22.69
UniProt: A0A6M4N019, A0A6G9KDV1
Pockets: 2 · best druggability 0.54

Structure

solution nmr · 2 distinct chains · 28% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	3C-like proteinase (EC 3.4.19.12, 3.4.22.69)	protein	96	30% helix, 20% strand	A0A6M4N019
B	Nucleoprotein	protein	73	25% helix, 0% strand	A0A6G9KDV1

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	296	0.54	0.75	28	empty
2	85	0.34	0.74	18	empty

Interfaces

1 interface between chains.

A–B · 1063 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

7PKU · Structure of SARS-CoV-2 nucleoprotein in dynamic complex with its viral partner nsp3a · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A6M4N019
Every structure of UniProt A0A6G9KDV1
Elsewhere: RCSB PDB 7PKU · PDBe 7PKU · UniProt A0A6M4N019 · UniProt A0A6G9KDV1

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