MolNFT v1 · #185217 · protein

NSP2 rnp complex

7PKP · Non-structural protein 2: “NSP2 rnp complex”. Electron microscopy, 20 pockets (best druggability 0.82). MolNFT v1 #185217 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7PKP
Type: protein
Length: 2,504 residues
Chains: 8
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Non-structural protein 2
EC: 3.6.4.-
UniProt: A2T3N6
Pockets: 20 · best druggability 0.82

Structure

electron microscopy · 1 distinct chain · 36% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
U, A, B, C, D, E, F, G	Non-structural protein 2 (EC 3.6.4.-)	protein	313	36% helix, 15% strand	A2T3N6

Pockets

20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	703	0.82	0.86	59	empty
2	710	0.82	0.86	56	empty
3	695	0.82	0.86	57	empty
4	704	0.81	0.85	56	empty
5	1131	0.73	0.76	90	empty

Interfaces

16 interfaces between chains.

U–E · 1144 Å² buried · 9 hydrogen bonds · protein-protein
A–D · 1144 Å² buried · 9 hydrogen bonds · protein-protein
C–F · 1139 Å² buried · 9 hydrogen bonds · protein-protein
B–G · 1136 Å² buried · 7 hydrogen bonds · protein-protein
B–C · 646 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

7PKP · NSP2 RNP complex · the same entry in another collection · chain U against U, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A2T3N6
Elsewhere: RCSB PDB 7PKP · PDBe 7PKP · UniProt A2T3N6

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