MolNFT v1 · #185168 · protein
Human voltage-gated potassium channel KV3.1 (with zn)
7PHI · Potassium voltage-gated channel, shaw-related subfamily…: “Human voltage-gated potassium channel KV3.1 (with zn)”. Electron microscopy, 3 ligands (PCF, ZN, K), 20 pockets (best druggability 0.82). MolNFT v1 #185168 on GenesisL1: 3D…
- PDB
- 7PHI
- Type
- protein
- Length
- 1,572 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Potassium voltage-gated channel, shaw-related subfamily, member 1
- UniProt
- Q3KNS8
- Ligands
- PCF, ZN, K
- Pockets
- 20 · best druggability 0.82
Structure
electron microscopy · 1 distinct chain · 62% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, B, D | Potassium voltage-gated channel, shaw-related subfamily, member 1 | protein | 393 | 62% helix, 7% strand | Q3KNS8 |
Ligands and binding sites
- PCF · 1,2-diacyl-sn-glycero-3-phoshocholine · ligand · 8 copies · chains A, C, B, D
- ZN · Zinc ion · metal · 4 copies · chains A, B, C, D
- K · Potassium ion · metal · 4 copies · chains A, C, B, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 837 | 0.82 | 0.85 | 44 | K |
| 2 | 810 | 0.81 | 0.84 | 53 | empty |
| 3 | 1035 | 0.77 | 0.79 | 110 | empty |
| 4 | 647 | 0.68 | 0.76 | 70 | empty |
| 5 | 610 | 0.67 | 0.76 | 64 | empty |
Interfaces
6 interfaces between chains.
- A–D · 3015 Ų buried · 22 hydrogen bonds · protein-protein
- C–D · 3015 Ų buried · 19 hydrogen bonds · protein-protein
- C–B · 3005 Ų buried · 20 hydrogen bonds · protein-protein
- A–B · 2991 Ų buried · 16 hydrogen bonds · protein-protein
- A–C · 35 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7PHI · Human voltage-gated potassium channel Kv3.1 (with Zn) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q3KNS8
- Elsewhere: RCSB PDB 7PHI · PDBe 7PHI · UniProt Q3KNS8
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