MolNFT v1 · #185061 · protein
Structure of adenylyl cyclase 9 in complex with darpin C4 and ATP-as
7PDG · Adenylate cyclase 9: “Structure of adenylyl cyclase 9 in complex with darpin C4 and ATP-as”. Electron microscopy, 19 pockets (best druggability 0.83). MolNFT v1 #185061 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7PDG
- Type
- protein
- Length
- 970 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Adenylate cyclase 9; Darpin C4
- UniProt
- E1BM79
- Pockets
- 19 · best druggability 0.83
Structure
electron microscopy · 2 distinct chains · 57% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Adenylate cyclase 9 | protein | 842 | 57% helix, 13% strand | E1BM79 |
| C | Darpin C4 | protein | 128 | 53% helix, 0% strand | — |
Pockets
19 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 384 | 0.83 | 0.91 | 50 | empty |
| 2 | 1032 | 0.83 | 0.83 | 100 | empty |
| 3 | 357 | 0.80 | 0.90 | 61 | empty |
| 4 | 544 | 0.74 | 0.82 | 70 | empty |
| 5 | 187 | 0.69 | 0.87 | 31 | empty |
Interfaces
1 interface between chains.
- A–C · 611 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 7PDG · structure of adenylyl cyclase 9 in complex with DARPin C4 and ATP-aS · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E1BM79
- Elsewhere: RCSB PDB 7PDG · PDBe 7PDG · UniProt E1BM79
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