MolNFT v1 · #185000 · protein
Cenp-hik 3-protein complex
7PB4 · Centromere protein H: “Cenp-hik 3-protein complex”. X-ray diffraction, 3 pockets (best druggability 0.65). MolNFT v1 #185000 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7PB4
- Type
- protein
- Length
- 353 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Centromere protein H; Centromere protein I; Centromere protein K
- UniProt
- Q9H3R5, Q92674, Q9BS16
- Pockets
- 3 · best druggability 0.65
Structure
x-ray diffraction · 3 distinct chains · 61% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | Centromere protein H | protein | 47 | 64% helix, 0% strand | Q9H3R5 |
| I | Centromere protein I | protein | 215 | 65% helix, 2% strand | Q92674 |
| K | Centromere protein K | protein | 91 | 49% helix, 10% strand | Q9BS16 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 340 | 0.65 | 0.79 | 36 | empty |
| 2 | 117 | 0.41 | 0.76 | 21 | empty |
| 3 | 79 | 0.37 | 0.77 | 21 | empty |
Interfaces
3 interfaces between chains.
- H–K · 1368 Ų buried · 5 hydrogen bonds · protein-protein
- H–I · 892 Ų buried · 10 hydrogen bonds · protein-protein
- I–K · 172 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 7PB4 · Cenp-HIK 3-protein complex · the same entry in another collection · chain H against H, TM-score 1.00
- Q92674 · AlphaFold monomer V2.0 prediction for centromere protein I (Q92674) · a predicted model of the same protein · chain I against A, TM-score 0.93
- Q9BS16 · AlphaFold monomer V2.0 prediction for centromere protein K (Q9BS16) · a predicted model of the same protein · chain K against A, TM-score 0.85
- Q9H3R5 · AlphaFold monomer V2.0 prediction for centromere protein H (Q9H3R5) · a predicted model of the same protein · chain H against A, TM-score 0.80
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9H3R5
- Every structure of UniProt Q92674
- Every structure of UniProt Q9BS16
- Elsewhere: RCSB PDB 7PB4 · PDBe 7PB4 · UniProt Q9H3R5 · UniProt Q92674 · UniProt Q9BS16
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