MolNFT v1 · #184852 · protein

Tetrameric structure of murine sapa

7P4T · Saposin-a: “Tetrameric structure of murine sapa”. X-ray diffraction, 3 pockets (best druggability 0.68). MolNFT v1 #184852 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7P4T
Type: protein
Length: 320 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Saposin-a
UniProt: Q61207
Pockets: 3 · best druggability 0.68

Structure

x-ray diffraction · 1 distinct chain · 79% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Saposin-a	protein	80	79% helix, 0% strand	Q61207

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	360	0.68	0.81	30	empty
2	370	0.68	0.80	26	empty
3	82	0.33	0.74	17	empty

Interfaces

6 interfaces between chains.

A–B · 665 Å² buried · 2 hydrogen bonds · protein-protein
C–D · 665 Å² buried · 2 hydrogen bonds · protein-protein
A–D · 501 Å² buried · 1 hydrogen bond · protein-protein
B–C · 367 Å² buried · 0 hydrogen bonds · protein-protein
A–C · 130 Å² buried · 2 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 12 disulfide (disulfide).

Compared structures

7P4T · Tetrameric structure of murine SapA · the same entry in another collection · chain A against A, TM-score 1.00
Q61207 · AlphaFold monomer V2.0 prediction for prosaposin (Q61207) · a predicted model of the same protein · chain A against A, TM-score 0.57

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q61207
Elsewhere: RCSB PDB 7P4T · PDBe 7P4T · UniProt Q61207

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