MolNFT v1 · #184761 · protein
Cryo EM structure of bison NHA2 in nano disc structure
7P1K · Mitochondrial SODIUM/HYDROGEN exchanger 9B2: “Cryo EM structure of bison NHA2 in nano disc structure”. Electron microscopy, 2 ligands (Y01, T7X), 20 pockets (best druggability 0.73). MolNFT v1 #184761 on GenesisL1: 3D structure…
- PDB
- 7P1K
- Type
- protein
- Length
- 866 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitochondrial SODIUM/HYDROGEN exchanger 9B2
- UniProt
- A0A6P3HVI0
- Ligands
- Y01, T7X
- Pockets
- 20 · best druggability 0.73
Structure
electron microscopy · 1 distinct chain · 74% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, A | Mitochondrial SODIUM/HYDROGEN exchanger 9B2 | protein | 433 | 74% helix, 0% strand | A0A6P3HVI0 |
Ligands and binding sites
- Y01 · Cholesterol hemisuccinate · ligand · 8 copies · chains B, A
- T7X · Phosphatidylinositol · ligand · 4 copies · chains B, A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 650 | 0.73 | 0.79 | 85 | empty |
| 2 | 571 | 0.73 | 0.80 | 65 | empty |
| 3 | 187 | 0.51 | 0.77 | 23 | empty |
| 4 | 216 | 0.48 | 0.75 | 35 | empty |
| 5 | 238 | 0.48 | 0.73 | 30 | empty |
Interfaces
1 interface between chains.
- B–A · 1455 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 7P1K · Cryo EM structure of bison NHA2 in nano disc structure · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A6P3HVI0
- Elsewhere: RCSB PDB 7P1K · PDBe 7P1K · UniProt A0A6P3HVI0
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