MolNFT v1 · #184581 · protein

Crystal structure of human filamin C domains 14-15 cardiovascular disease causing mutation S1624L

7OUV · Isoform 2 of filamin-C: “Crystal structure of human filamin C domains 14-15 cardiovascular disease causing mutation S1624L”. X-ray diffraction, 6 pockets (best druggability 0.56). MolNFT v1 #184581 on GenesisL1: 3D structure…

PDB: 7OUV
Type: protein
Length: 406 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Isoform 2 of filamin-C
UniProt: Q14315
Pockets: 6 · best druggability 0.56

Structure

x-ray diffraction · 2 distinct chains · 4% helix, 52% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Isoform 2 of filamin-C	protein	204	4% helix, 52% strand	Q14315
B	Isoform 2 of filamin-C	protein	202	4% helix, 51% strand	Q14315

Pockets

6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	175	0.56	0.80	30	empty
2	125	0.45	0.77	22	empty
3	69	0.40	0.80	23	empty
4	89	0.37	0.76	20	empty
5	74	0.34	0.76	18	empty

Interfaces

1 interface between chains.

A–B · 405 Å² buried · 4 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

7OUV · Crystal structure of human filamin C domains 14-15 cardiovascular disease causing… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q14315
Elsewhere: RCSB PDB 7OUV · PDBe 7OUV · UniProt Q14315

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