MolNFT v1 · #184566 · protein
High resolution structure of alpha-1-acid glycoprotein bound to potent anti-tumour compound ucn-01
7OUB · Alpha-1-acid glycoprotein 2: “High resolution structure of alpha-1-acid glycoprotein bound to potent anti-tumour compound ucn-01”. X-ray diffraction, 1 ligand (UCN), 1 pocket (best druggability 0.75). MolNFT v1 #184566 on GenesisL1…
- PDB
- 7OUB
- Type
- protein
- Length
- 173 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alpha-1-acid glycoprotein 2
- UniProt
- P19652
- Ligands
- UCN
- Pockets
- 1 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 19% helix, 42% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Alpha-1-acid glycoprotein 2 | protein | 173 | 19% helix, 42% strand | P19652 |
Ligands and binding sites
- UCN · 7-hydroxystaurosporine · ligand · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 386 | 0.75 | 0.85 | 31 | UCN |
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 7OUB · High resolution structure of Alpha-1-acid glycoprotein bound to potent anti-tumour… · the same entry in another collection · chain B against B, TM-score 1.00
- P19652 · AlphaFold monomer V2.0 prediction for alpha-1-acid glycoprotein 2 (P19652) · a predicted model of the same protein · chain B against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19652
- Elsewhere: RCSB PDB 7OUB · PDBe 7OUB · UniProt P19652
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.