MolNFT v1 · #184559 · protein

The structure of muts bound to two molecules of ADP

7OU2 · DNA mismatch repair protein muts: “The structure of muts bound to two molecules of ADP”. Electron microscopy, 1 ligand (ADP), 12 pockets (best druggability 0.77). MolNFT v1 #184559 on GenesisL1: 3D structure, binding sites and…

PDB: 7OU2
Type: protein
Length: 1,371 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA mismatch repair protein muts
UniProt: A0A0B1MR81
Ligands: ADP
Pockets: 12 · best druggability 0.77

Structure

electron microscopy · 2 distinct chains · 47% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	DNA mismatch repair protein muts	protein	721	47% helix, 17% strand	A0A0B1MR81
B	DNA mismatch repair protein muts	protein	650	48% helix, 16% strand	A0A0B1MR81

Ligands and binding sites

ADP · Adenosine-5'-diphosphate · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

12 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1114	0.77	0.79	104	empty
2	881	0.75	0.79	72	empty
3	759	0.74	0.79	98	ADP
4	344	0.64	0.80	54	empty
5	521	0.64	0.76	36	empty

Interfaces

1 interface between chains.

A–B · 2641 Å² buried · 15 hydrogen bonds · protein-protein

Compared structures

7OU2 · The structure of MutS bound to two molecules of ADP · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A0B1MR81
Elsewhere: RCSB PDB 7OU2 · PDBe 7OU2 · UniProt A0A0B1MR81

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