MolNFT v1 · #184511 · protein

Cryo-EM structure of nonameric epec sctv-C

7OSL · Translocator escv: “Cryo-EM structure of nonameric epec sctv-C”. Electron microscopy, 20 pockets (best druggability 0.80). MolNFT v1 #184511 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7OSL
Type: protein
Length: 2,935 residues
Chains: 9
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Translocator escv
UniProt: B7UMA7
Pockets: 20 · best druggability 0.80

Structure

electron microscopy · 2 distinct chains · 43% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C, D, E, F, G, H, I	Translocator escv	protein	326	43% helix, 23% strand	B7UMA7
B	Translocator escv	protein	327	43% helix, 23% strand	B7UMA7

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	891	0.80	0.82	107	empty
2	882	0.79	0.82	113	empty
3	963	0.79	0.81	120	empty
4	814	0.76	0.80	81	empty
5	622	0.75	0.82	79	empty

Interfaces

9 interfaces between chains.

H–I · 1200 Å² buried · 10 hydrogen bonds · protein-protein
A–I · 1200 Å² buried · 11 hydrogen bonds · protein-protein
F–G · 1199 Å² buried · 10 hydrogen bonds · protein-protein
A–B · 1198 Å² buried · 11 hydrogen bonds · protein-protein
G–H · 1197 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

7OSL · Cryo-EM structure of nonameric EPEC SctV-C · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt B7UMA7
Elsewhere: RCSB PDB 7OSL · PDBe 7OSL · UniProt B7UMA7

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