MolNFT v1 · #184509 · protein

ABC transporter complex nosdfyl, membrane anchor

7OSJ · Probable ABC transporter binding protein nosd: “ABC transporter complex nosdfyl, membrane anchor”. Electron microscopy, 3 ligands (MG, CU, ZN), 16 pockets (best druggability 0.82). MolNFT v1 #184509 on GenesisL1: 3D structure…

PDB: 7OSJ
Type: protein
Length: 1,673 residues
Chains: 6
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Probable ABC transporter binding protein nosd; Probable ABC transporter ATP-binding…
UniProt: P19843, P19844, P19845, Q52529
Ligands: MG, CU, ZN
Pockets: 16 · best druggability 0.82

Structure

electron microscopy · 6 distinct chains · 39% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Probable ABC transporter binding protein nosd	protein	392	7% helix, 34% strand	P19843
B	Probable ABC transporter ATP-binding protein nosf	protein	308	34% helix, 20% strand	P19844
C	Probable ABC transporter ATP-binding protein nosf	protein	307	30% helix, 21% strand	P19844
D	Probable ABC transporter permease protein nosy	protein	267	77% helix, 0% strand	P19845
E	Probable ABC transporter permease protein nosy	protein	248	75% helix, 0% strand	P19845
H	Copper-binding lipoprotein nosl	protein	151	27% helix, 11% strand	Q52529

Ligands and binding sites

MG · Magnesium ion · metal · chains A
CU · Copper (II) ion · metal · chains A, H
ZN · Zinc ion · metal · chains H

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

16 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1119	0.82	0.83	124	empty
2	947	0.80	0.82	78	empty
3	106	0.77	0.96	28	empty
4	517	0.75	0.83	53	empty
5	454	0.62	0.76	54	empty

Interfaces

8 interfaces between chains.

B–C · 2472 Å² buried · 34 hydrogen bonds · protein-protein
C–D · 1150 Å² buried · 14 hydrogen bonds · protein-protein
B–E · 1136 Å² buried · 14 hydrogen bonds · protein-protein
A–H · 1134 Å² buried · 12 hydrogen bonds · protein-protein
A–D · 878 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

7OSJ · ABC Transporter complex NosDFYL, membrane anchor · the same entry in another collection · chain H against H, TM-score 1.00
P19843 · AlphaFold monomer V2.0 prediction for probable ABC transporter binding protein nosd… · a predicted model of the same protein · chain A against A, TM-score 0.96
P19845 · AlphaFold monomer V2.0 prediction for probable ABC transporter permease protein nosy… · a predicted model of the same protein · chain E against A, TM-score 0.95
P19844 · AlphaFold monomer V2.0 prediction for probable ABC transporter ATP- binding protein nosf… · a predicted model of the same protein · chain B against A, TM-score 0.94
Q52529 · AlphaFold monomer V2.0 prediction for copper-binding lipoprotein nosl (Q52529) · a predicted model of the same protein · chain H against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P19843
Every structure of UniProt P19844
Every structure of UniProt P19845
Every structure of UniProt Q52529
Elsewhere: RCSB PDB 7OSJ · PDBe 7OSJ · UniProt P19843 · UniProt P19844 · UniProt P19845 · UniProt Q52529

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