Crystal structure of the L452R mutant receptor binding domain of SARS- cov-2 spike glycoprotein in complex with covox-75 and covox-253 fabs

Structure

x-ray diffraction · 7 distinct chains.

Ligands and binding sites

• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 8 copies · chains R, H, X, C
• FUC · alpha-L-fucopyranose · sugar · 4 copies · chains H, C
• BMA · beta-D-mannopyranose · sugar · 3 copies
• MAN · alpha-D-mannopyranose · sugar · 3 copies
• CL · Chloride ion · ion · 4 copies · chains H, L, C, D, E, F
• PO4 · Phosphate ion · ion · 3 copies · chains H, A, X, E, C
• GOL · Glycerol · additive · 16 copies · chains R, H, L, A, B, X, C, D, E, F
• PEG · Di(hydroxyethyl)ether · additive · 4 copies · chains R, X, D, E, F
• TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · 2 copies · chains R, L, X, D
• BTB · 2-[bis-(2-hydroxy-ethyl)-amino]-2-hydroxymethyl-propane-1,3-diol · additive · chains E

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7ORB · Crystal structure of the L452R mutant receptor binding domain of SARS-CoV-2 Spike… · the same entry in another collection · chain R against R, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P0DTC2
• Elsewhere: RCSB PDB 7ORB · PDBe 7ORB · UniProt P0DTC2