MolNFT v1 · #184434 · protein

Nak S-di mutant soaked in na+

7OQ2 · Potassium channel protein: “Nak S-di mutant soaked in na+”. X-ray diffraction, 3 ligands (NA, K, CL), 2 pockets (best druggability 0.47). MolNFT v1 #184434 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7OQ2
Type: protein
Length: 186 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Potassium channel protein
UniProt: Q81HW2
Ligands: NA, K, CL
Pockets: 2 · best druggability 0.47

Structure

x-ray diffraction · 2 distinct chains · 77% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Potassium channel protein	protein	91	78% helix, 0% strand	Q81HW2
B	Potassium channel protein	protein	95	77% helix, 0% strand	Q81HW2

Ligands and binding sites

NA · Sodium ion · metal · 4 copies · chains A, B
K · Potassium ion · metal · 2 copies · chains A, B
CL · Chloride ion · ion · 2 copies · chains A, B
MPD · (4S)-2-methyl-2,4-pentanediol · additive · 18 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	67	0.47	0.83	19	empty
2	57	0.27	0.73	13	empty

Interfaces

1 interface between chains.

A–B · 1036 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

7OQ2 · NaK S-DI mutant soaked in Na+ · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q81HW2
Elsewhere: RCSB PDB 7OQ2 · PDBe 7OQ2 · UniProt Q81HW2

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